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| -Genomic Data for HLH-14 |
Links |
- Gene
- hlh-14
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- Species
- $species
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- Domain
- bHLH
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- IHOP
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47563
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- Swiss-Prot
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Q09961
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- UniPROBE Accession Number
- $accession_id
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- Synonyms
- None Available
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- $refseq_designator
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NP_495131
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- Wormbase Protein ID
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WP:CE36629
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- EdgeDB Promoter
- Phlh-14
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- Wormbase Gene ID
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WBGene00001958
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- Description (from Wormbase)
- hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa.
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| -PBM Motif Data for HLH-14 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
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View
Save
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- Top Kmer
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AAAAAAAA E.S. 0.402
TTTTTTTT E.S. 0.402
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- Downloads
-
Download the
zip
of all HLH-14 PBM files
or view the
downloads directory
for individual files.
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| -PBM Motif Data for HLH-2/HLH-14 Heterodimer |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
- View
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- Top Kmer
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ACA.CTGTC E.S. 0.488
GACAG.TGT E.S. 0.488
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- Downloads
- Download the zip of all HLH-2/HLH-14 interaction files or view the downloads directory for individual files.
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| -HLH-14 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
|
hlh-14
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No |
Not full length |
2014-07-16 |
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- HLH-14 Insert Sequence
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1 AKKNQVARNE RERKRVHQVN HGFDVLRNRL QPKNHTKKWS KADTLREAVK
51 YIQQLQVLLN QDPQQPSVSS STPDYTMNNS NNFNNYAVKE EFSMYLPQNY
101 CPQNQMSVPH GDVSHNFNSP TSSVSSSSYS PTQMCYPPVS YSNYPHH
- Mutations away from WormBase HLH-14 wildtype:
- • Methioinine start not included in insert sequence
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| HLH-14 Interacts With |
Clone Type |
Last Modified |
Save |
View |
| HLH-2 |
Full length clone |
2008-07-23 |
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