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| -Genomic Data for MDL-1 |
Links |
- Gene
- mdl-1
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- Species
- $species
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- Domain
- bHLH
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- IHOP
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45830
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- Swiss-Prot
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Q21663
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- UniPROBE Accession Number
- $accession_id
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- Synonyms
- None Available
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- $refseq_designator
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NP_509136
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- Wormbase Protein ID
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WP:CE04784
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- EdgeDB Promoter
- Pmdl-1
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- Wormbase Gene ID
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WBGene00003163
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- Description (from Wormbase)
- mdl-1 encodes a basic helix-loop-helix (bHLH) protein similar to the vertebrate MAD transcriptional regulators; in vitro, MDL-1 can heterodimerize, and bind an E-box DNA sequence, with MXL-1, a C. elegans MAX-like bHLH protein; when expressed in rat embryonic fibroblasts, MDL-1 is able to suppress c-MYC/RAS-induced cell transformation, in a manner dependent upon an intact, predicted SIN3 interaction domain; mdl-1::gfp promoter fusions are expressed in a number of different tissues, including the posterior intestine, anterior and ventral cord neurons, pharyngeal and body wall muscles, somatic gonad precursors, and hypodermal cells; yeast one-hybrid and ChIP experiments indicate that DAF-3/Smad can bind the mdl-1 promoter; in addition, mdl-1 pharyngeal expression is specifically increased in daf-3(RNAi) animals, suggesting that DAF-3 directly negatively regulates mdl-1 transcription in pharyngeal tissue during dauer formation.
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| -PBM Motif Data for MDL-1 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
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View
Save
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- Top Kmer
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ATTCAGAG E.S. 0.405
CTCTGAAT E.S. 0.405
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- Downloads
-
Download the
zip
of all MDL-1 PBM files
or view the
downloads directory
for individual files.
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| -PBM Motif Data for MXL-1/MDL-1 Heterodimer |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
- View
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- Top Kmer
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CCACGTGC E.S. 0.498
GCACGTGG E.S. 0.498
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- Downloads
- Download the zip of all MXL-1/MDL-1 interaction files or view the downloads directory for individual files.
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| -MDL-1 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
|
mdl-1
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No |
Full length clone |
2014-07-16 |
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- MDL-1 Insert Sequence
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1 EQQLNLGHLL TAARLLDIGA LDISSLDLGA LTSTSSSPGS SSPAMFELSN
51 ESELRSLFCG KLKVDKKQSS CASNASTSSQ PYCSSPPARK SSKHSRTAHN
101 ELEKTRRANL RGCLETLKML VPCVSDATRN TTLALLTRAR DHIIELQDSN
151 AAQMKKLNDL RDEQDELVAE LAQLQADEEV AQATSQACQT LSQSRPESRA
201 SSFTSTSSRD SPCYLEYSPS SKPMDSHKPT IIDLYAEGLI PRGPITFPRP
251 LVYPHNVFDL MNLPPTPFDV SQFLPINLQV
- Mutations away from WormBase MDL-1 wildtype:
- • Methioinine start not included in insert sequence
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| MDL-1 Interacts With |
Clone Type |
Last Modified |
Save |
View |
| MXL-1 |
Full length clone |
2008-07-23 |
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