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View All Genomic Data PBM Motif Data PBM Clones Minimize All

-Genomic Data for GFI1				Links
Protein GFI1	UniPROBE Accession Number UP00591	Species Homo sapiens	Domain zf-C2H2	Swiss-Prot Q99684
Name and Synonyms Name: zinc finger protein Gfi-1. Synonyms:FLJ94509, GFI-1, Growth factor independent protein 1, SCN2, Zinc finger protein 163, Zinc finger protein Gfi-1, ZNF163				IHOP 88602
				NCBI RefSeq NP_005254
Description Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.				JASPAR None Available

-PBM Motif Data for GFI1_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble) Reverse Complement (RC)				PWM Save
				Top Kmer AAATCAC.G E.S. 0.496 C.GTGATTT E.S. 0.496
Downloads Download the zip of all GFI1_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-PBM Motif Data for GFI1_L400F_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble) Reverse Complement (RC)				PWM Save
				Top Kmer AAATCAC.G E.S. 0.496 C.GTGATTT E.S. 0.496
Downloads Download the zip of all GFI1_L400F PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-PBM Motif Data for GFI1_N382S_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble) Reverse Complement (RC)				PWM Save
				Top Kmer ATATCAC.G E.S. 0.486 C.GTGATAT E.S. 0.486
Downloads Download the zip of all GFI1_N382S PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

Download Data for GFI1 (all alleles)
Downloads Download the zip of all GFI1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-GFI1 Datasets
Clone	Clone Type	Last Modified	Save	View
GFI1_REF	DNA binding domain only
GFI1_REF Insert Sequence 1    HADKGAGVKV ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS 51   GTRPFACEMC GKTFGHAVSL EQHKAVHSQE RSFDCKICGK SFKRSSTLST 101  HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT FIHTGEKPHK CQVCGKAFSQ 151  SSNLITHSRK HTGFKPFGCD LCGKGFQRKV DLRRHRETQH GLK
GFI1_L400F	DNA binding domain only
GFI1_L400F Insert Sequence 1    HADKGAGVKV ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS 51   GTRPFACEMC GKTFGHAVSL EQHKAVHSQE RSFDCKICGK SFKRSSTLST 101  HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT FIHTGEKPHK CQVCGKAFSQ 151  SSNLITHSRK HTGFKPFGCD FCGKGFQRKV DLRRHRETQH GLK
GFI1_N382S	DNA binding domain only
GFI1_N382S Insert Sequence 1    HADKGAGVKV ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS 51   GTRPFACEMC GKTFGHAVSL EQHKAVHSQE RSFDCKICGK SFKRSSTLST 101  HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT FIHTGEKPHK CQVCGKAFSQ 151  SSSLITHSRK HTGFKPFGCD LCGKGFQRKV DLRRHRETQH GLK
References Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016