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| -Genomic Data for Nr2f6 |
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- Protein
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- UniPROBE Accession Number
- UP01381
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- Species
- Mus musculus
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- Domain
- zf-C4
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- Swiss-Prot
- P43136
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- Name and Synonyms
- Name: Nuclear receptor subfamily 2 group F member 6.
Synonyms:AV090102, COUP-TF3, COUP transcription factor 3, Ear2, EAR2, Ear-2, EAR-2, Erbal2, V-erbA-related protein 2
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- IHOP
- 120845
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- NCBI RefSeq
- NP_034280
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- Description
- Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).
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- JASPAR
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MA0677.1
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| -PBM Motif Data for Nr2f6 |
- PBM-Derived DNA Binding Site Motif
(Seed-And-Wobble)
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- PWM
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Save
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- Top Kmer
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AAAGGTCA E.S. 0.497
TGACCTTT E.S. 0.497
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- Downloads
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Download the
zip
of all Nr2f6 PBM files
or view the downloads directory for individual files.
Please note that the files which include probe sequence data are protected by an academic research use license,
which can be viewed here.
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| -Nr2f6 Datasets |
| Gene |
Clone Type |
Last Modified |
Save |
View |
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Nr2f6 |
DNA binding domain only |
2017-05-12 |
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- Nr2f6 Insert Sequence
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1 GATSDAEPGD EERPGLQVDC VVCGDKSSGK HYGVFTCEGC KSFFKRTIRR
51 NLSYTCRSNR DCQIDQHHRN QCQYCRLKKC FRVGMRKEAV QRGRIPHALP
101 G
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- References
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Data are analyzed by array designs with AMADID #s 016060, 015681 in Mariani et al., Cell Systems 2017
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